Visualizing Our Tech Worship With Giant Webs of Circuitry




For Italian artist Leonardo Ulian, this is our universe. At its center: a microchip. Beyond: resistors, capacitors, inductors, transistors. Ulian’s “technological mandalas”—webs of circuitry in the form of the Hindu or Buddhist symbolic diagrams of the cosmos—are icons for an electronic age, and he’ll be exhibiting them this fall in Milan. Each mandala, the biggest of which is nearly 5 feet across, takes two weeks to create and requires as many as a thousand parts (mostly purchased from Russian sellers on eBay). They’re meant to trigger deeper questions about our relationship with technology. “People nowadays almost worship electronics,” he says. “I wouldn’t be surprised to hear that someone has created a religion based on microchips.” Chant with us: ohm …



Mother Superior


If you visit Sen.se Mother’s website, your first reaction might be to get creeped out. The product is billed as “like a mom, only better.” The company’s tagline is “the meaning of life.” Sen.se says that “Mother knows everything,” and with this device, your mom has been given “a slight upgrade.”


That’s weird. And Mother looks like a little ghost with glowing LED eyeballs, so it’s also a bit spooky. But rather than making all your nightmares come true, this fascinating and unique system can actually be pretty useful. It may even be the blueprint for how the “Internet of Things” can garner mainstream adoption.


So what does Mother actually do? Many things. It’s a stat-keeper, a data-visualizer, and a life coach. It won’t control the smartware you already have, but it does eliminate the need for a few single-purpose devices, such as door sensors and basic fitness trackers. Rather than assembling data from other devices, Mother analyzes and visualizes input from its own little freewheeling sensors, which you can put on your keychain, your toothbrush, your front door, under the fitted sheet in your bed, on grandpa’s bottle of heart pills, or on your coffee machine. You can also set up each sensor to make cartoony sound effects when shaken. This I did for a good five minutes.


After plugging Mother in and connecting it to your router, you finish setup in the browser and by performing tasks that tear down the fourth wall between real and electronic worlds. While configuring it, you immediately realize this gadget is not like the others.


In order to activate the base unit, the browser software prompts you to “Delicately touch [Mother] between the eyes.” To initialize its sensors—they’re called Motion Cookies—an on-screen prompt asks you to place them close to the base unit, tap one with your finger to help Mother recognize it, and then pick it up after it’s been recognized. Once you do, a round of applause blasts out of your computer’s speakers. It’s engaging, fun, and a little bit startling. Mother has “weird in a good way” down to a science.


Each Mother base unit comes with its own name. Mine was born Precious Josefa, but I quickly renamed it Albino Grimace. Whatever you want to call it, each 6.3-inch-tall duckpin-with-a-face plugs into a power source and your router with an included Ethernet cable. It acts as an in-home broadcast tower that sends and receives transmissions over its own ISM band, using the two-inch-long Cookies as its data tendrils. Four Cookies come with Mother, but each base unit supports incoming data from up to 24 Cookies; additional four-packs of Cookies are sold for $160.


While the base unit gives the system its oddball personality, it’s the Cookies and the software that are the real stars of the show. Think of the Cookies as freelance sensors. Each one runs on a user-replaceable CR2016 coin cell battery, which is rated for a year of battery life. The Cookies have built-in accelerometers and temperature sensors, which you can (re)configure with ease.


You can quickly assign them to create reports of your walking and running stats, tell you whenever your door opens, and provide a chart of your sleep cycles. You can also opt to have Mother send reminders, dispense advice, and offer words of encouragement (“You should pick up a toothbrush now,” “You’re way behind your [walking] target. Leave your couch and put on your shoes,” etc.). If you get tired of a certain application, you can reassign each Cookie to do something else. Number-crunching is done in the cloud after Mother absorbs your Cookie data.


The Cookies are color-coded and have unique two-word names printed on them—oddly poetic monikers like “brisk cupcake” and “known loquat”—making them easy to identify while programming and reprogramming them. You assign functions using apps available on Senseboard, a browser-based dashboard with visualization tools for everything you’re tracking. Current apps include Walk, Sleep, Door, Teeth, Medication, Presence, Temperature, Check, and Coffee. A mobile app for iOS, Android, and Windows Phone displays your dashboard, but Cookie assignments need to be done in the browser.


After the unique setup process, the system sort of fades into the background and gets to work. In my tests, I used the Walk app to track my daily mileage and calorie burning, the Sleep app to gauge my slumber patterns, the Door app to let me know whenever anyone entered or left my apartment, the Teeth app to track my brushing habits, and the Temperature app to get readings from all my Cookies. The well-done Senseboard helps the cause, with easy-to-parse sortable charts that cleanly display daily and long-term data.


Senseboard typos aside (“Sweat dreams”), I was impressed by the Sleep app. It was eerily accurate despite being powered by a thumbdrive-sized sensor tucked beneath my sheets. When I had a bad night’s sleep, Mother knew it. When I had a particularly good one—in terms of quality, not quantity—it was also spot-on. One morning, I had a nightmare and woke up yelling at a murder-beast, and you could pinpoint the time it happened, between 5 and 6 a.m., in that night’s sleep chart.


The Walk app also worked well. I attached a Cookie to my keychain with one of the rubbery shells included in the box, which also can be used as a toothbrush mount. As compared to the other apps, which are built for in-home use close to the Mother base unit, there’s one big drawback in using a Cookie as a fitness tracker: You don’t get live, up-to-date stats unless you’re in Wi-Fi range of a Mother. It doesn’t have to be your own base station. Being within range of a friend’s base station—your brother with another Mother—will update your own account with your stats. Luckily, there’s plenty of time to sidle up to Mother, as the Cookies offer 10 days worth of memory and transmit your stats once a base station is in range.


There are a few weak spots. One of my four Cookies (“thin mochi”) didn’t work. According to Sen.se, the first batch of Cookies they made had issues, but the problem is fixed in shipping units. While email alerts and words of encouragement are free, you need to purchase a “credit pack” that costs $5 to $20 in order to receive text-message alerts from the system. And while Mother is the kind of thing you’ll try and immediately like—I didn’t initially take to the idea of tracking mundane tasks such as teeth-brushing and temperature-watching, but it grew on me—$300 is a steep price for taking the plunge. However, if you think of it in terms of how many items it could potentially replace, $300 is a bargain.


Ultimately, there is a lot to be excited about here. Mother is a weird and wonderful little ecosystem, and this platform and its structure have a lot of room for growth. The sensors and the software are bound to grow in versatility. According to Sen.se CEO Rafi Haladjian, the company is planning to open its API so that apps, smart devices, and services such as IFTTT can tap into Mother’s magic. Don’t fear the weird. Mother is innovative, and potential abounds.



How the XPrize Foundation Is Building Our Next-Gen Health Sensors


from Star Trek: The Next Generation.

Dr. Beverly Crusher uses a tricorder to scan Chief Engineer Geordi La Forge aboard the USS Enterprise, from Star Trek: The Next Generation. Paramount



Apple and Google aren’t the only ones pushing for a new generation of wearables and gadgets that can monitor your health from minute to minute.


As the two tech giants invite a world of developers to create health apps and devices that dovetail with Apple iOS and Android gear, the XPrize Foundation—that not-for-profit champion of incentivized innovation—is running the Nokia Sensing XChallenge, using cash prizes to spark the development of new sensor technologies that address healthcare problems and help people generally monitor their well-being. This week, the organization selected eleven projects to vie for the grand prize, including a smartphone-based tool that aims to provide early diagnosis for diabetic retinopathy, a leading cause of blindness in adults; a sensor that can help monitor patients with chronic heart failure; and a sensor that detects sleep apnea.


The winners are set to be determined this November at the Exponential Medicine conference in San Diego, California. The grand prize is $525,000, and five runners up will receive $120,000. It’s part of a much larger movement that seeks to redefine healthcare through sensing technology. Some of these efforts are rather questionable, but XPrize is among those hoping to bring some legitimacy to the movement—and ultimately win FDA approval for these new types of devices.


Round Number Two


This is the contest’s second go round. The Nokia Sensing XChallenge was first announced in 2012, with the idea that it would be held twice over the next two years, and that it would feed into a bigger, $10 million challenge: the Qualcomm Tricorder XPRIZE. True to its name, this prize aims to a create a universal, Star Trek-inspired medical diagnostic tool that detects up to 16 separate health conditions.


EyeMITRA is a phone-based tool that provides early diagnosis for diabetic retinopathy, a leading cause of blindness in adults.

EyeMITRA is a phone-based tool that provides early diagnosis for diabetic retinopathy, a leading cause of blindness in adults. XPRIZE



The original Sensing XChallenge, says Grant Campany, senior director of the competition, was set up as a starting point for the identification and collection of promising technologies for the Tricorder XPRIZE. But after the competition got underway, most teams decided that they wanted to refine their technologies instead of pivoting them for the future Tricorder challenge, and for Campany, that ended up creating stronger individual technologies.


“The Nokia Sensing XChallenge provides an objective means by which these technologies can be evaluated, and is also an opportunity to increase awareness of these technologies around the world,” Campany says. “It engages the general public on what’s just around the corner.”


This year, only one of the teams—Cambridge, Massachusetts-based DMI, which designed a sensor that assesses hundreds of clinical lab tests using a single drop of blood—is also a Tricorder finalist. Campany says that the finalists of the competition have a mix of motivations. Some teams formed because members had an idea for a product that was ripe for commercialization, and others were university academics and students who simply wanted to delve deeper into sensor technology research.


Ahead of the Curve


How close are the projects to widespread distribution? That varies on a case-by-case basis, according to Campany. One of the biggest challenges teams face is how to distill the vast body of data collected by sensors into usable information. Another is navigating regulatory questions, many of which have never been asked before, since the inventions are brand new. “It’s complicated to be involved in research that’s so far ahead of the curve that regulatory boards don’t even have the guidelines yet,” Campany says.


One way the organization is dealing with the problem is by forming a relationship with the U.S. Food and Drug Administration, the federal agency that pronounces whether a new diagnostic tool can be cleared for public use. For the Tricorder XPRIZE, the foundation arranged for teams to have direct access to a help desk comprised of 18 FDA volunteers. And so the collaboration forced the FDA to face these new questions, which could accelerate the approval of similar technologies they encounter in the future.


All the while, the competition acts as a breeding ground for cutting edge ideas in sensing technology. Last year, according to competition organizers, the big trend that emerged was lab-on-a-chip. This year, teams made great strides in using photonics sensors to gather information on environmental contaminants and blood chemistry.


But what has been most rewarding as someone working in this space, Campany says, is the opportunity to put the finalists’ research up on a big stage—and getting them some much-needed funding. “What’s been really fun for us is seeing prize winners walking out of the room and meeting investors in the same venue,” he says. “That kind of attention bringing money to these teams that would otherwise be having a much greater struggle is really gratifying.”



Week’s Best TV: Jimmy Kimmel Fires a Lightning Gun and The Simpsons Go Kubrick


The password to enter the latest edition of our best TV roundup is Fidelio, because that’s only fitting when Stanley Kubrick takes the top line spot by proxy. The Simpsons returned to the LED throne this week with a fantastic 25th edition of its annual “Treehouse of Horror” variety show, but perennial bestie John Oliver follows close on their heels with a damning indictment (as usual) of how the United States government treats translators working in its service. To lighten that load we’ve got some silly science popping off and some even sillier Keanu Reeves—much preferred to his Sad counterpart—as part of a Jimmy Kimmel twofer. Oh, and another thing you guys, Selfie is happening, so you best get on board before you get left behind. Just like we told you it would. The prophecy is fulfilled with the following clips from this past week in television.


The Simpsons—Treehouse of Horror XXV


The granddaddy of Sunday’s animation block is really stepping up its game this season. In the first episode of the season, they turned the iconic opening credits into a futuristic freakshow from the mind of Don Hertzfeldt. Sure, they’ve done couch gags before, but this one was truly nuts—and amazing. Then this week, we got to walk back into the Halloween Treehouse of Horror for the 25th time. This is the complete second act of the show, and it’s an outstanding tribute to Stanley Kubrick. The only thing harder than fluidly adapting Anthony Burgess’ Nadsat parlance to screen, as Kubrick so masterfully did with A Clockwork Orange, might be fluidly imitating it in a way that feels at once like parody and tribute, as The Simpsons did on Sunday with A Clockwork Yellow. Moe takes on the role of Alex, leading his droogs on a spree of ultra hijinks through Springfield. Fortunately, it’s a lot less murdery and rapey than the source material, and the whole bit is just stacks on stacks on stacks of nods to the ultra-weird auteur. Keep your eyes wide open for this one so you don’t miss anything!


Last Week Tonight with John Oliver—Translators


“Are you ready for this shit? Let’s do it!”


Jimmy Kimmel Live!—Exploding Paint Cans & Lightning Guns With Science Bob Pflugfelder


It’s pretty entry-level stuff, but 10 minutes of fun with science on late night TV? We’ll take it!


Brooklyn Nine-Nine—Halloween Bet


It’s Halloween, and that means Detective Peralta (Andy Samberg) and Captain Holt (Andre Braugher) have their annual holiday wager to make! Last year, Peralta bet Holt he could steal his Medal of Valor, which was child’s play compared to this year’s challenge: the watch right off his wrist. So the con is on, and Peralta will once again need the services of his squad room to pull this one off. See their deft execution of the caper above.


Selfie—Nugget of Wisdom


File under: John Cho is our secret dream best friend. Uh-oh. Secret’s out!


Jimmy Kimmel Live!—Jimmy Kimmel Asks Keanu Reeves Random Questions


Is Keanu Reeves America’s best kept secret? Yes, we all know his name, but it’s clear we have no idea who he really is. More random questions with Keanu. And more ghost stories, please!


Modern Family—Won’t You Be Our Neighbor?


The Dunphys’ neighbors are moving out, and Phil is handling the sale, which means they’ve got a prime position to cherry pick the ideal new family next door. So when the perfect candidates show up, Phil and Claire are hell bent on “seducing” them into the sale by advertising the house’s number one feature: its “Dunphy Adjacency.” But in the whirlwind of their hard sales pitch, signals get a little mixed, and the pageant frontrunners for Best New Neighbor drop out. See how it fell apart, and see Sarah Hyland’s excellent face be the MVP of this scene.


Bonus Track: The Tonight Show Starring Jimmy Fallon—Bradley Cooper and Jimmy Fallon Can’t Stop Laughing (Uncut)


We are not even kidding when we say this is 11 minutes of Bradley Cooper and Jimmy Fallon falling apart on the Tonight Show. Is this peak laughter? In a career filled with scene-killing character breaks, Fallon may have finally passed the laughter event horizon, never to be seen or heard from again (until the next night, obviously, when he has to do another show).



Naim Does the Impossible: Build a Soundbar Even Audiophiles Love


Unless you’re an audiophile, you’ve probably never heard of Naim. This hi-fi brand is known for two things: sticker shock (their flagship amplifier is $240k), and reference-quality components that defy obsolescence (Naim Aro tonearms, introduced in 1989, still sell briskly on eBay). Now, the British purveyors of high-end audio nirvana have accomplished the seemingly impossible: Build a soundbar that will make even the most hardcore audiophiles melt in their listening chair.


Of course, the dreaded S-word is never mentioned. The Naim website refers to the mu-so as a “wireless music system” instead. Don’t kill the copywriter. Any company that makes a soundbar capable of crushing the stereos found in most white collar homes can call their little box any euphemism they damn well please. The nitpicking audio press, which favors tower speakers and 50-pound pre-amps over Wi-Fi antennae and digital-filtering algorithms, has already lavished the mu-so with enough praise to make industry execs nervous. If the legendary “Naim sound” is now bundled into a $1,500 soundbar, who will buy all those $43,000 Opus speaker cables?


With just a couple reviews under its belt, Naim’s new soundbar is still a best-kept secret. Calling the mu-so a soundbar, though, is like calling Einstein a bright guy. This is basically a pimped out boombox for millennials weaned on Wi-Fi. To begin with, it pumps out serious lease-breaking power: 450 watts. No, that’s not a typo. The speakers are pretty special, too. No OEM parts here. All six active drivers are custom-designed by Naim’s crackerjack team sonic. You want fancy? The high notes are filtered through silk dome tweeters instead of the standard metal cones, and the “audio brain” of this rig is a 32bit/234khz digital signal processor capable of 150 million calculations per second. This DSP runs proprietary code that controls, among other things, the “bespoke EQ system.” That may sound like Anglophile marketing hooey, but it’s not. There are two room settings, for instance, to optimize the sound signature when the mu-so is placed near or away from wall. Audiophile tip: The closer speakers are to a wall, the bigger the bass response.


And speaking of bass, there’s plenty of it. All of it tuned to perfection by a patented port designed to reduce resonance, lower distortion, and deliver “serious kick for powerful music performance.” And it looks good doing it. From the acrylic base, which gives the illusion of an objet d’art floating in space, to the touch-panel volume control made from a solid ring of bead-blasted anodized aluminum, to the four interchangeable speaker grills, to placate interior designers and finicky girlfriends, the mu-so is a shelter magazine icon in waiting.


Here’s the rub, though: The Naim mu-so is a gateway drug that will lead to late-onset OCD and financial ruin. It may start innocently enough: streaming ALAC files from an iPhone, sampling the Mood Booster playlist on Spotify, maybe blasting Urge Overkill while screening Pulp Fiction on the Vizio. Sure, the expansive and thoroughly convincing soundstage this Mighty Mouse unit projects is downright eerie. And the iOS/Android app, with all its customization options and metadata, is certainly convenient. But this glorious honeymoon will end. Eventually you’ll find yourself pricing Bentleys and toying with the idea of selling your house and moving to Kentucky in order to afford a “proper Naim sound system.” Listen to this thing at your own risk.



A gut bacterium that attacks dengue and malaria pathogens and their mosquito vectors

Just like those of humans, insect guts are full of microbes, and the microbiota can influence the insect's ability to transmit diseases. A study published on October 23rd in PLOS Pathogens reports that a bacterium isolated from the gut of an Aedes mosquito can reduce infection of mosquitoes by malaria parasites and dengue virus. The bacterium can also directly inhibit these pathogens in the test tube, and shorten the life span of the mosquitoes that transmit both diseases.



George Dimopoulos and colleagues from Johns Hopkins University, USA, had previously isolated Csp_P, a member of the family of chromobacteria, from the gut of Aedes aegypti mosquitoes (which transmit dengue fever) in Panama. In the present study, they examined its actions on both mosquitoes and pathogens, and the results suggest that Csp_P might help to fight malaria and dengue fever at different levels.


The researchers added Csp_P to sugar water fed to mosquitoes and found that the bacteria are able to quickly colonize the gut of the two most important mosquito disease vectors, namely Aedes aegypti and Anopheles gambiae (the latter transmit malaria). Moreover, the presence of Csp_P in the gut reduced the susceptibility of the respective mosquitoes to infection with the malaria parasite Plasmodium falciparum or with dengue virus. And even without gut colonization, exposure to Csp_P through food or breeding water shortened the lifespan of adult mosquitoes and mosquito larvae of both species.


When the researchers tested whether Csp_P could act against the malaria or dengue pathogens directly, they found that the bacterium, likely through production of toxic metabolites, can inhibit growth of Plasmodium at various stages during the parasite's life cycle, and also abolish dengue virus infectivity. In addition, Csp_P can inhibit growth of many other bacteria.


The authors suggest that these toxic metabolites could potentially be developed into therapeutic drugs for malaria and dengue. Overall, they conclude that "its broad-spectrum anti-pathogen properties together with its ability to kill mosquitoes make Csp_P a particularly interesting candidate for the development of novel control strategies for the two most important vector-borne diseases, and they therefore warrant further in-depth study."




Story Source:


The above story is based on materials provided by PLOS . Note: Materials may be edited for content and length.



Rapid test to diagnose severe sepsis

A new test, developed by University of British Columbia researchers, could help physicians predict within an hour if a patient will develop severe sepsis so they can begin treatment immediately.



Sepsis, a syndrome caused by infection, leads to organ failure and is responsible for up to five million deaths annually. There are 18 million cases of sepsis worldwide every year.


The discovery could cut back on the lengthy diagnostic time usually required to confirm if a patient is suffering from sepsis and increase the odds that they will respond to treatment.


"We identified a gene signature that is associated with the eventual diagnosis of sepsis and subsequent organ failure," says Bob Hancock, a professor in UBC's Dept. of Microbiology and Immunology who co-authored this study with John Boyd, a physician at St Paul's Hospital and an assistant professor at UBC. "We can test for this genetic signature as soon as the patient arrives in the emergency ward."


A typical diagnosis can take 24 to 48 hours but with this new test, physicians could start treating patients almost immediately.


The new test for the genetic signature, published recently in the journal EBioMedicine, would take as little as one hour and identified 96 per cent of patients who were at the very early stages of sepsis.


"With sepsis, every hour counts," says Hancock. "The treatment involves aggressive antibiotics but the most potent drugs can't be administered until a diagnosis is confirmed because of the risk of antibiotic resistant bacteria."


The findings also reveal a potential misunderstanding about the disease. Until now sepsis has been treated as an inflammatory disease but more than 30 clinical trials of anti-inflammatory drugs for sepsis have failed. The gene signature identified by Hancock and his colleagues relates to a special type of immune suppression called cellular reprogramming and suggests that treating inflammation in sepsis is a bad idea.




Story Source:


The above story is based on materials provided by University of Faculty of Science British Columbia . Note: Materials may be edited for content and length.